New Orleans is a major United States port and the largest city and metropolitan area in the state of Louisiana. The Central Business District of New Orleans is located immediately north and west of the Mississippi River and was historically called the “American Quarter” or “American Sector.” The New Orleans region accounts for a significant portion of the nation’s oil refining and petrochemical production and serves as a white-collar corporate base for onshore and offshore petroleum and natural gas production. New Orleans is also a center for higher learning, with over 50,000 students enrolled in the region’s eleven higher education institutions. A top-50 research university, Tulane University, is located in New Orleans’ Uptown neighborhood. New Orleans is a major regional hub for the health care industry and boasts a small, globally competitive manufacturing sector. The center city possesses a rapidly growing, entrepreneurial creative industries sector and is renowned for its cultural tourism.